The story encircles on the Estrada family, their lives, scandals, loves, betrayals and the mystery behind their father Jacinto's Estrada disappearance.
Apparently, he went missing after failing to pursue his dreams of becoming a doctor and was presumed dead. Estrada has three daughters -Silvia, Lisa and Beatriz and a son Augusto Estrada who became the guardian of his sisters after their mother died. She was buried next to her husband's grave.
With no one left to care for the family, Augusto who refuses to part with his siblings shoulders the responsibility of bringing up the girls. Well, one can say he makes great sacrifices to forget his dreams/ambitions and dedicates his life to keep the family together.
Augusto is married to Margarita Alvarez who is a selfish woman who is tired of living in virtual poverty and sharing the same roof as Augusto's sisters. When Margarita sells supplies to a contracting building where engineer Santiago Ortega works, she sets her eyes on him and they sleep together with Margarita claiming she is not married.
The eldest girl Silvia becomes a maternal figure and helps run the household. She was called 'General' because she likes to give orders and want everything to be perfect.
She married to Carlos Salas and the mother of twins. Carlos is finding it hard to get a job and they move in Augusto's home.
Lisa develops a strong emotional dependency on Augusto. She was called 'Miss Perfect'. She works as a nurse and at the same time she takes medical courses at the university to become a doctor. She run into Santiago who is contracted to build a mall on the land adjoining the hospital where Lisa works. Lisa argues with Santiago because she is certain that their clinic will be demolished so as to allow for the expansion of the new shopping mall and this starts them on a journey of love filled with obstacles.
And the youngest one is Beatriz or Beba which she ends up being everybody's 'daughter'. Beatriz who has trouble in school academically falls in love with Francisco Moreno.
After listening to some rumours, Augusto was convinced that Francisco is a criminal and a bad influence to Beatriz. Augusto is determined to make sure Francisco stays away from Beatriz and his high expectations of Beatriz academically is too much for Beatriz.
Santiago Ortega is a handsome engineer who at the same time already engaged to Barbara Solis, the daughter of the owner of the company he works for. After falling in love with Lisa (without knowing the woman he'd sleep with is her sister-in-law), she broke up with his fiancee, Barbara. Barbara tries to commit suicide when Santiago breaks off his engagement to her and Ernesto Solis (Barbara's father) is determined to take his revenge on Santiago by framing him for the death of a worker on the construction site.
As the story unfolds, Lisa comes face-to-face with her long lost father Jacinto, who now is her co-worker, mentor and advisor at the hospital where she's working.
It was later learnt that Jacinto who deserted his family, had resorted to alcohol due to the hardships he faced raising the family. He had an accident and lost his memory. Although he regained his memories later, he did not go back to his family but instead stayed with his now wife, Delia.
Jacinto realises that he should have been there for his children.
Lisa becomes very attached to Jacinto as they work together to investigate an epidemic. Although she and her sisters could forgives him, Augusto was very upset and felt that his father is a coward who abandoned his family.
Finally after all the hard times and obstacles, the lovebirds - Lisa and Santiago gets married. There are triplets wedding where Lisa with Santiago, Augusto with Barbara and Beatriz with Francisco. Augusto and Barbara are a little weird. Didn't expect them to be a couple.
Augusto met Barbara and she wanted to tell Augusto the truth about his wife but then Augusto is really upset and worried about her sister Beatriz which is now in the hospital, ill because of the epidemic.
Annibal Solis is Barbara's brother.
Margarita went her own way and in the final scene she was seen being poisoned by a man, belived to be either her lover/husband who wants her money.
Silvia and Carlos who already had twins, now have triplets!
Lisa and Santiago, Augusto and Barbara; they all have childrens.